Mouse Study Indicates Metformin May Increase Lifespan.
USA Today Share to FacebookShare to Twitter (7/30, Weintraub) reports that a study in mice suggests that metformin may increase lifespan “by a number of weeks – the human equivalent of 3-4 years.” According to Rafael de Cabo, a biogerontologist at the National Institute of Aging, who conducted the study, “It’s clear that we are edging toward developing a pharmaceutical intervention that is going to be able to delay or postpone aging,” but “for how much and how long I have no idea.” The findings were published in Nature Communications.
BBC News Share to FacebookShare to Twitter (7/31, Briggs) reports that de Cabo said, “These are very promising results that need to be translated to humans via clinical studies.”
MedPage Today Share to FacebookShare to Twitter (7/31, Fiore) reports that mice “given daily feed containing 0.1% metformin had an average 5.83% increase in lifespan compared with control mice that didn’t get the drug (P=0.02),” although “the lifespan of mice given feed that contained 1% metformin was significantly shortened by 14.4%, indicating a sweet spot for chronic, beneficial doses of the” medication.
HealthDay Share to FacebookShare to Twitter (7/31, Preidt) reports that the data indicated that metformin increased “the use of fat for energy in mice and it also helped them maintain body weight as they” got older. Additionally, the rodents given metformin “had lower rates of cataracts,” and the medication “prevented the onset of metabolic syndrome.”
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